3-Nitroaniline, 98%

ANALYTYKA Fine Chemicals and Pharmaceutical Raw Materials

3-Nitroaniline, 98%

1. Product Identification

Synonyms: m-Nitroaniline; 3-Nitrobenzenamine; 3-Nitrophenylamine
CAS No.:  99-09-2
Molecular Weight: 138.0542
Chemical Formula: NO2C6H4NH2
Product Codes: N0038

2. Composition/Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
99-09-2 3-Nitroaniline 98 202-729-1


3. Hazards Identification


Appearance: yellow.
Caution! Possible risks of irreversible effects. Methemoglobin former - can cause cyanosis. May cause eye and skin irritation. May cause respiratory and digestive tract irritation. May be harmful if swallowed. This substance has caused adverse reproductive and fetal effects in animals.
Target Organs: Blood, kidneys, liver, blood forming organs.

Potential Health Effects
Eye: May cause eye irritation. Vapors may cause eye irritation. May cause eye injury.
Skin: May cause skin irritation. Substance is rapidly absorbed through the skin. If absorbed, may cause symptoms similar to those for ingestion.
Ingestion: May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. Effects may be delayed 2 to 4 hours. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Alcohol can intensify effects.
Inhalation: May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation of aniline causes anoxia due to the formation of methemoglobin.
Chronic: May cause liver and kidney damage. May cause bone marrow abnormalities with damage to blood forming tissues. May cause anemia and other blood cell abnormalities. Repeated exposure may cause central nervous system damage. Adverse reproductive effects have been reported in animals.

4. First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately.
Skin: Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood. Cleansing of the entire contaminated area of the body is of utmost importance.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

5. Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May decompose explosively when heated or involved in a fire.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Flash Point: Not applicable.
Autoignition Temperature: 521 deg C ( 969.80 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 1; Instability: 2

6. Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

7. Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale.
Storage: Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.

8. Exposure Controls, Personal Protection

Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
3-Nitroaniline none listed none listed none listed

OSHA Vacated PELs: 3-Nitroaniline: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

9. Physical and Chemical Properties

Physical State: Solid
Appearance: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: 4.8
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 306 deg C
Freezing/Melting Point:114 deg C
Decomposition Temperature:> 396 deg C
Solubility: Insoluble in water.
Specific Gravity/Density:Not available.
Molecular Formula:NO2C6H4NH2
Molecular Weight:138.0542

10. Stability and Reactivity

Chemical Stability: Stable. However, may decompose if heated.
Conditions to Avoid: High temperatures, ignition sources, dust generation, excess heat.
Incompatibilities with Other Materials: Strong acids, strong oxidizing agents, strong reducing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

11. Toxicological Information

CAS# 99-09-2: BY6825000
CAS# 99-09-2:
     Oral, mouse: LD50 = 308 mg/kg;
     Oral, rat: LD50 = 535 mg/kg;

CAS# 99-09-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: Animal studies have demonstrated fetoxicity (growth retardation) and teratogenicity (exencephaly, angulated ribs, dilated brain ventricles).
Teratogenicity: No information available.
Reproductive Effects: No information available.
Mutagenicity: No information available.
Neurotoxicity: No information available.
Other Studies:

12. Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: No information available.
Physical: No information available.
Other: None.

13. Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

14. Transport Information

  US DOT Canada TDG
Hazard Class: 6.1 6.1
UN Number: UN1661 UN1661
Packing Group: II II


15. Regulatory Information


     CAS# 99-09-2 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 99-09-2: immediate, delayed, reactive.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 99-09-2 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
Risk Phrases:

     R 23/24/25 Toxic by inhalation, in contact with skin and if
     R 33 Danger of cumulative effects.
     R 52/53 Harmful to aquatic organisms, may cause long-term adverse
     effects in the aquatic environment.

Safety Phrases:

     S 28 After contact with skin, wash immediately with...
     S 36/37 Wear suitable protective clothing and gloves.
     S 45 In case of accident or if you feel unwell, seek medical advice
     immediately (show the label where possible).
     S 28B After contact with skin, wash immediately with plenty of water
     and soap.
     S 61 Avoid release to the environment. Refer to special instructions
     /safety data sheets.

WGK (Water Danger/Protection)

     CAS# 99-09-2: 2
Canada - DSL/NDSL
     CAS# 99-09-2 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D1A, D2A.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 99-09-2 is listed on the Canadian Ingredient Disclosure List.

16. Other Information

Product Use:
Laboratory Reagent.
Revision Information:
Jan. 2008.
ANALYTYKA provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. ANALYTYKA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, ANALYTYKA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.