Caffeine, Anhydrous, U.S.P/N.F.
Caffeine, Anhydrous, U.S.P/N.F.
1. Product Identification
Synonyms: 3,7-Dihydro-1,3,7-Trimethyl-1H-Purine-2,6-Dione;
Xanthrine,1,3,7-Trimethyl; Anhydrous Caffeine; Methyl Theobromide
CAS No.: 58-08-2
Molecular Weight: 194.0956
Chemical Formula:
C8H10N4O2
Product Codes: C0019
2. Composition/Information on Ingredients
|
CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 58-08-2 |
CAFFEINE |
ca 100 |
200-362-1 |
3. Hazards
Identification
EMERGENCY OVERVIEW
Appearance: white solid.
Warning! Harmful if swallowed. May cause eye and skin
irritation. May cause respiratory tract irritation. May cause digestive tract
irritation with nausea, vomiting, and diarrhea. May cause cardiac disturbances.
May cause adverse reproductive effects. May cause central nervous system
effects.
Target Organs: Heart, central nervous system.
Potential Health Effects
Eye: Dust may cause mechanical irritation.
Skin: May cause skin irritation.
Ingestion: Harmful if swallowed. May cause gastrointestinal
irritation with nausea, vomiting and diarrhea. Ingestion increases the metabolic
rate causing warm, flushed and moist skin, muscular weakness, rapid heart rate,
insomnia, nervousness, increased metabolism and weight loss. May cause ataxia,
blood pressure elevation, convulsions, hallucinations, hypermotility, muscle
contraction or spasticity, somnolence (general depressed activity), toxic
psychosis, and tremors.
Inhalation: May cause respiratory tract irritation. May cause
effects similar to those described for ingestion.
Chronic: May cause digestive tract and cardiac disturbances.
May cause reproductive and fetal effects.
4. First Aid
Measures
Eyes: Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Flush skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes. Get medical aid if irritation
develops or persists. Wash clothing before reuse.
Ingestion: Call a poison control center. If swallowed, do not
induce vomiting unless directed to do so by medical personnel. Never give
anything by mouth to an unconscious person. Get medical aid.
Inhalation: Remove from exposure and move to fresh air
immediately. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.
5. Fire Fighting
Measures
General Information: As in any fire, wear a self-contained
breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and
full protective gear. During a fire, irritating and highly toxic gases may be
generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical,
chemical foam, or alcohol-resistant foam. Use agent most appropriate to
extinguish fire.
Flash Point: Not applicable.
Autoignition Temperature: 540 deg C ( 1,004.00 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 2; Flammability: 0;
Instability: 0
6. Accidental Release Measures
General Information: Use proper personal protective equipment
as indicated in Section 8.
Spills/Leaks: Clean up spills immediately, observing
precautions in the Protective Equipment section. Sweep up, then place into a
suitable container for disposal. Avoid generating dusty conditions. Provide
ventilation.
7. Handling and
Storage
Handling: Provide ventilation. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with skin and eyes. Do
not ingest or inhale. Wash clothing before reuse.
Storage: Store in a tightly closed container. Store in a cool,
dry, well-ventilated area away from incompatible substances.
8. Exposure
Controls, Personal Protection
Engineering Controls: Use process enclosure, local exhaust
ventilation, or other engineering controls to control airborne levels below
recommended exposure limits.
Exposure Limits
|
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| CAFFEINE |
none listed |
none listed |
none listed
|
OSHA Vacated PELs: CAFFEINE: No OSHA Vacated PELs are listed
for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety
goggles as described by OSHA's eye and face protection regulations in 29 CFR
1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin
exposure.
Clothing: Wear appropriate protective clothing to minimize
contact with skin.
Respirators: Follow the OSHA respirator regulations found in 29 CFR
1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN
149 approved respirator if exposure limits are exceeded or if irritation or
other symptoms are experienced.
9. Physical and
Chemical Properties
Physical State: Solid
Appearance: white
Odor: odorless
pH: Not available.
Vapor Pressure: Negligible.
Vapor Density: Not available.
Evaporation Rate:Negligible.
Viscosity: Not available.
Boiling Point: 177.8 deg C
Freezing/Melting Point:237.8 deg C
Decomposition Temperature:Not available.
Solubility: Slightly soluble in water.
Specific Gravity/Density:1.23
Molecular Formula:C8H10N4O2
Molecular Weight:194.0956
10. Stability and
Reactivity
Chemical Stability: Stable at room temperature in closed containers under
normal storage and handling conditions.
Conditions to Avoid: Incompatible materials, dust generation, excess
heat.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide,
irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
11. Toxicological
Information
RTECS#:
CAS# 58-08-2: EV6475000
LD50/LC50:
CAS# 58-08-2:
Oral, mouse: LD50 = 127 mg/kg;
Oral, rabbit: LD50 = 224 mg/kg;
Oral, rat: LD50 = 192 mg/kg;
.
Carcinogenicity:
CAS# 58-08-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: Experimental reproductive effects have been reported.
Teratogenicity: A human teratogen, causes developmental abnormalities of
the craniofacial and musculoskeletal systems, pregnancy termination and
stillbirth.
Reproductive Effects: See above.
Mutagenicity: No information available.
Neurotoxicity: No information available.
Other Studies:
12. Ecological
Information
Ecotoxicity: No data available. No information available.
Environmental: TERRESTRIAL FATE: If released to soil, estimated soil
adsorption indicate that caffeine will display very high mobility. An estimated
Henry's Law constant of 1.9X10-19 atm-cu m/mole at 25 deg C indicates that it
will not volatilize from moist soil to the atmosphere. AQUATIC FATE: If released
to water caffiene will not bioconcentrate aquatic organisms. ATMOSPHERIC FATE:
Exists predominantly in the particulate phase, half life 2.5 hours. Expected to
biodegrade but not bioconcentrate.
Physical: No information available.
Other: No information available.
13. Disposal
Considerations
Chemical waste generators must determine whether a discarded
chemical is classified as a hazardous waste. US EPA guidelines for the
classification determination are listed in 40 CFR Parts 261.3. Additionally,
waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
14. Transport
Information
| |
US DOT |
Canada TDG |
| Shipping Name: |
ALKALOIDS, SOLID, N.O.S. |
No information available. |
| Hazard Class: |
6.1 |
|
| UN Number: |
UN1544 |
|
| Packing Group: |
III |
|
15. Regulatory
Information
US FEDERAL
TSCA
CAS# 58-08-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 58-08-2: immediate.
Section 313 No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances
under the CWA.
None of the chemicals in this product are listed as Priority Pollutants
under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants under
the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by
OSHA.
STATE
CAS# 58-08-2 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level: None of the chemicals in this product are
listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 58-08-2: 1
Canada - DSL/NDSL
CAS# 58-08-2 is listed on Canada's DSL List.
Canada - WHMIS
not available.
This product has been classified in accordance with the hazard criteria of the
Controlled Products Regulations and the MSDS contains all of the information
required by those regulations.
Canadian Ingredient Disclosure List
16. Other Information
Product Use:
Laboratory Reagent.
Revision Information:
Jan. 2008.
Disclaimer:
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ANALYTYKA provides the information contained herein in good faith but makes
no representation as to its comprehensiveness or accuracy. This document is
intended only as a guide to the appropriate precautionary handling of the
material by a properly trained person using this product. Individuals
receiving the information must exercise their independent judgment in
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REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT
LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR
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WHICH THE INFORMATION REFERS. ACCORDINGLY, ANALYTYKA WILL NOT BE RESPONSIBLE FOR
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