4-Bromoaniline

1. Product Identification

Synonyms: p-Bromoaniline; p-bromophenylamine
CAS No.: 106-40-1
Molecular Weight: 172.02
Chemical Formula: C6H6BrN
Product Codes: B0123, B0124

2. Composition/Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
106-40-1	4-Bromoaniline	> 96	203-393-9

3. Hazards Identification

EMERGENCY OVERVIEW

Appearance: gray to brown crystals.
Warning! Harmful if swallowed, inhaled, or absorbed through the skin. Causes eye, skin, and respiratory tract irritation. May cause methemoglobinemia. May cause liver and kidney damage.
Target Organs: Blood, kidneys, liver, respiratory system, eyes, skin.

Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation. Harmful if absorbed through the skin.
Ingestion: Harmful if swallowed. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea.
Inhalation: May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Inhalation of aniline causes anoxia due to the formation of methemoglobin.
Chronic: May cause liver and kidney damage. Prolonged exposure may cause anemia and methemoglobinemia, characterized by dizziness, drowsiness, headache, breath shortness, cyanosis (bluish skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood.

4. First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician: For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.

5. Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: ; Flammability: ; Instability:

6. Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Reduce airborne dust and prevent scattering by moistening with water. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation.

7. Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage: Store in a cool, dry place.

8. Exposure Controls, Personal Protection

Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
4-Bromoaniline	none listed	none listed	none listed

OSHA Vacated PELs: 4-Bromoaniline: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

9. Physical and Chemical Properties

Physical State: Crystals
Appearance: gray to brown
Odor: characteristic odor
pH: Not available.
Vapor Pressure: 0.0429 mm Hg @ 25 deg C
Vapor Density: 5.9
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:60-65 deg C
Decomposition Temperature:Not available.
Solubility: Insoluble in cold water.
Specific Gravity/Density:1.497
Molecular Formula:C6H6BrN
Molecular Weight:172.02

10. Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Dust generation, excess heat.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide.
Hazardous Polymerization: Will not occur.

11. Toxicological Information

RTECS#:
CAS# 106-40-1: BW9280000
LD50/LC50:
CAS# 106-40-1:
     Oral, mouse: LD50 = 289 mg/kg;
     Oral, rat: LD50 = 456 mg/kg;
.

Carcinogenicity:
CAS# 106-40-1: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: No information available.
Mutagenicity: No information available.
Neurotoxicity: No information available.
Other Studies:

12. Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: Terrestrial: Not expected to leach into groundwater. Aquatic: Attaches to sediment. Atmospheric: Exists solely in vapor phase with a half life of two days. Biodegraded by Moraxella spp. Bioconcentrates slightly.
Physical: No information available.
Other: No information available.

13. Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

14. Transport Information

	US DOT	Canada TDG
Shipping Name:	TOXIC SOLIDS, ORGANIC, N.O.S.	Not Regulated
Hazard Class:	6.1	(9.2)
UN Number:	UN2811
Packing Group:	III

15. Regulatory Information

US FEDERAL

TSCA
     CAS# 106-40-1 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 106-40-1: immediate.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 106-40-1 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     XN
Risk Phrases:
     R 20/21/22 Harmful by inhalation, in contact with skin and if
     swallowed.
     R 36/37/38 Irritating to eyes, respiratory system and skin.

Safety Phrases:
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
     otection.

WGK (Water Danger/Protection)
     CAS# 106-40-1: No information available.
Canada - DSL/NDSL
     CAS# 106-40-1 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 106-40-1 is not listed on the Canadian Ingredient Disclosure List.

16. Other Information

Product Use:
Laboratory Reagent.
Revision Information:
Jan. 2008.
Disclaimer:
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ANALYTYKA provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. ANALYTYKA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, ANALYTYKA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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